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11 October 2019

Cannabinoids in medicine Part 2: Pain

In the second of a series of five articles, Oxford Cannabinoid Technologies will discuss their expertise on the use of cannabinoids in medicine. Following the first article that discussed the treatment of cancer, this second piece will focus on the use of cannabinoids to treat pain. Cannabinoids are active molecules found within the cannabis plant and include CBD and THC, two of the most notable cannabinoids currently being studied.

In the U.S. alone, the number of individuals suffering from chronic pain is close to 100m,1 with two-thirds of patients feeling that current medication does not meet their needs.2 More people suffer from chronic pain than cancer, heart disease and diabetes combined.3 Patients use cannabis to treat multiple forms of pain, with cannabis shown to address neuropathic (burning or lancinating), mechanical (dullness or aching) and inflammatory (acute or sharp) pain components or sensations.

Cannabinoid receptors are expressed in the peripheral and central nervous systems, as well as on immune cells. Pre-clinical data, in vivo animal model studies and a small number of clinical trials in acute, neuropathic, chronic and cancer pain models suggest that CB1 and CB2 receptors play an important role in pain processing and that modulation of the endocannabinoid system can alleviate pain.

Read the full article here

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